The purpose of this work was to develop an oral dispersible film of repaglinide utilizing pullulan as a polymer and analyze it using various criteria. Drug-excipient tests were conducted utilizing fourier transmission infrared spectroscopy (FT-IR) to identify potential incompatibilities. The oral dispersible films were created utilizing the solvent casting process with Pullulan as the polymer. Polyoxyethylene was employed as a plasticiser. The produced films were assessed for physical appearance, thickness, folding durability, in-vitro disintegration, mechanical characteristics, surface pH, drug content homogeneity, taste assessment, in-vitro dissolution test and stability analysis. The T6 formulation was determined to be more optimised, stable and adequate in terms of assessment parameters than other formulations. The folding endurance was 282±1.59, disintegration time was 05±0.57, thickness was 0.064±0.001, tensile strength was 5.89, % elongation was 26.08 and maximal drug release was 95.90% in 30 minutes. The drug content was determined to be 99.90, with a surface pH of 6.4. The formulation's stability experiments revealed that the product remained stable for 90 days. The oral dispersible film is simple to give and extremely successful for patients and the created film of repaglinide is a promising option for safe and effective oral dispersible drug administration.
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